Low-Pressure Silica Gel Liquid Chromatography Column System

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DAC (Dynamic Axial Compression) columns are core equipment in industrial preparative chromatography. They utilize high-pressure axial compression technology, dynamically adjusting the column bed pressure through a piston to ensure uniform, stable, and compact packing, effectively preventing column bed collapse. Suitable for applications from laboratory research to industrial production, they meet the demands of high-purity separation and purification.

 

The main process of DAC unit is as above, and it is composed with high pressure feeding pump, UV detector, DAC column, work station, pipe system, control system, etc.

 

1. Excellent Column Efficiency and Stability
Employs dynamic axial compression technology to maintain a consistently uniform column bed, resulting in high efficiency, excellent peak symmetry, stable performance, and strong reproducibility.

Ideal for large-scale preparative columns with internal diameters of 50 mm or more, effectively addressing challenges associated with linear scale-up.

2. Intelligent Pressure Control
The piston is equipped with a specialized sealing ring that allows smooth sliding under high sealing pressure, maintaining constant column pressure and preventing bed loosening or channeling.

Supports operating pressures of 10 MPa and higher, meeting the requirements of high-pressure preparative chromatography.

3. High-Quality and Corrosion-Resistant Materials
Column tube, piston, and sieve plate are constructed from corrosion-resistant materials such as 316L stainless steel or PTFE. The internal surface finish is ≤0.2 μm, complying with GMP standards.

Glass columns are also available to accommodate different solvent systems and pH ranges.

4. Flexible Compatibility and Customization
Compatible with various packing types, including silica gel, hybrid particles, and ion-exchange resins, with particle sizes ranging from 1.8 μm to 50 μm.

Customizable internal diameters from 25.4 mm to 800 mm to suit different throughput requirements.

5. Automation and Intelligent Control
Integrated PLC control system enables real-time monitoring of pressure, temperature, and flow rate, supporting remote operation and data logging.

Pneumatic-hydraulic system enables fully automated column packing, pressure maintenance, and unpacking.

 

1. Pharmaceutical Industry
Purification of active pharmaceutical ingredients (APIs), separation of chiral compounds, and extraction of natural products such as fish oil EPA/DHA, vitamins, and alkaloids.

2. Food and Nutraceuticals
Extraction of high-purity functional components including polyphenols, pigments, and sweeteners.

3. Fine Chemicals
Purification of dyes, surfactants, fragrances, and polymer monomers.

4. Biotechnology
Separation and purification of proteins, peptides, and nucleic acids.

 

Q1: What are the advantages of DAC columns over traditional packing methods?
A: DAC technology uses dynamic pressure control to prevent column bed collapse, resulting in higher efficiency and longer column life, making it particularly suitable for large-scale preparative applications.

Q2: Are DAC columns compatible with corrosive solvents?
A: Yes. Materials such as 316L stainless steel, titanium alloy, or PTFE can be selected to withstand a wide range of organic solvents and acidic/alkaline conditions.

Q3: How do I select the appropriate particle size?
A: Smaller particle sizes (1.8–5 μm) are suitable for high-resolution analysis, while larger particle sizes (20–50 μm) are recommended for high-throughput preparative applications.

Q4: Do you provide packing services?
A: Yes, we offer a one-stop service including packing selection, column packing, and efficiency testing.

 

For further technical details, customized solutions, or a quotation, please contact us via email or phone. We are committed to providing professional technical support and solutions.

 

 

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We emphasize progress and introduce new merchandise into the market each and every year for Low-Pressure Silica Gel Liquid Chromatography Column System. Our company is oriented to meet the needs of users and is constantly committed to the development of new technologies. We set professional service standards, realize every promise to customers, and truly be timely.