Introduction
The core of industrial preparative chromatography lies in achieving precise separation by leveraging differences in the distribution coefficients of components between the stationary and mobile phases. Our system incorporates an innovative Dynamic Axial Compression Chromatography design. The integrated hydraulic system applies continuous and stable axial pressure to the column bed, fundamentally ensuring a uniform and densely packed stationary phase. This effectively eliminates channeling and wall effects, establishing a solid foundation for high-efficiency separations.
Landerlee has rich experience of column chromatography column technology device, and has provided a lot of industrial size columns to natural plant extraction companies and medicine companies.
Structure
This industrial size chromatography column unit is composed of solvent wash tank, blending reactor, feeding pump, elution tank, column, meters, valves, etc.
Advantages
1. Superior Separation Performance
High Resolution: Specially designed distributor ensures uniform flow. Dynamic compression enhances bed stability and prevents channeling. Theoretical plate number reaches 5000 per meter; resolution >1.8.
Minimal Scale-Up Effect: Geometric similarity-based scaling maintains consistency from lab to production scale. Linear scale-up to 1000× with RSD <2%.
High Re
covery: Target recovery ≥98%; integrated solvent recovery system recycles >90% of solvent.
2. Ease of Operation and Maintenance
High Automation: Automated packing and loading within 30 minutes; one-click method transfer from lab to production; CIP reduces manual effort.
Easy Maintenance: Modular design enables quick parts replacement; self-diagnostic function alerts for maintenance; remote technical support available.
3. Economic Benefits
Low Operating Costs: Reduces solvent use by >40%, energy consumption by 30%, and labor cost by 50%.
Improved Product Quality: Purity >99.5%; impurity reduction by one order of magnitude; batch-to-batch consistency RSD <1%.
Application
1. Pharmaceutical Industry
Chemical API Purification: Chiral resolution (ee >99.5%), antibiotics, and anticancer drugs (e.g., paclitaxel).
Biopharmaceuticals: Peptide purification, insulin, monoclonal antibody fragments (Fab/Fc).
Traditional Chinese Medicine: Extraction of active compounds (alkaloids, flavonoids, saponins), injectable ingredients, and standardized extracts.
2. Natural Product Extraction
Plant Extracts: CBD isolation (THC <0.3%), ginkgo extract (>24% flavonolactones), paclitaxel (>99.5%).
Food Additives: Natural pigments, sweeteners, and functional ingredients (e.g., resveratrol, curcumin).
3. Fine Chemicals
Electronic Chemicals: Ultra-pure reagents, LCD materials, photoresists.
New Materials: Polymer monomers, specialty intermediates, reference standards.
five Reasons to Choose Our Systems
1.Extensive Experience: 12 years in industry; over 300 clients.
2.Reliable Quality: Key imported components; full traceability.
3.High Cost-Effectiveness: Import-level quality; local pricing.
4.Customization Support: Tailored to process needs.
5.Training Programs: Improves operational skills.
our factory
packing
Hot Tags: industrial size chromatography column technology device, China, manufacturers, suppliers, factory, customized, CBD Ethanol Extraction Facility, solvent reclamation, tobacco solvent extraction device, adsorption and partition column chromatography, magnetic seal molecular distillation device, centrifugal filtration equipment