Description

Introduction

SF-SMB stands for supercritical simulated moving bed chromatography, which is a high-efficiency green chromatography equipment. It uses supercritical CO₂ as the mobile phase. The low-cost and clean and sustainable method is especially suitable for the separation of various lipophilic small molecules. It can be used in the fields of biomedicine, natural raw materials, and fine chemicals.

It is a chromatographic separation and purification equipment that combines high efficiency, low energy consumption, as well as safety, environmental protection and other advantages.

Structure

It is composed with supercritical CO₂ extraction device and simulated moving bed chromatography.

Features

1) Continuous working, magnificently increase capacity;

2) It uses supercritical CO₂ as mobile phase during the whole process, which is easy to recover and reuse, and saves solvent cost;

3) Higher efficiency and lower energy consumption;

4) Magnificently decrease the use of organic solvent, makes the process more economical and more environmentally friendly;

5) Applies international famous brand accessories, stable and reliable; 

6) ASME standard of pressure vessels;

7) Excellent quality to ensure efficient and stable operation of equipment.

Model

1. Lab size SF-SMB

1) P-SFSMBC-PX

This model is a preparative-grade supercritical fluid simulation moving bed. It can be equipped with 6 to 12 separation columns with diameters ranging from 30 mm to 50 mm. User can choose standard stainless steel packed columns or upgrade to SAC columns; you can also choose to use organic liquid or supercritical CO2 as the running solvent. When CO2 is used, it can be completely recycled and used.

2) P-SFSMBC/E-PX

This model is specially designed for SF-SMB equipment that requires supercritical fluid extraction, mainly adding supercritical fluid extraction function on the P-SFSMBC-PX device. You can use 5L supercritical CO₂ extraction device to extract product at first, then with P-SFSMBC-PX to do purification process.

3) KG-SFSMBC-DX

This is a more capable SMB. It uses 6 to 12 columns DAC, with size ranging from 80mm to 120mm. You can also use SAC as chromatography column. Mobile phase is also flexible, you can choose between organic liquid or supercritical CO₂.

4) KG-SFSMBC/E-DX

We assemble 5L supercritical CO₂ extraction device and KG-SFSMBC-DX together. You can use 5L supercritical CO₂ extraction device to extract product at first, then with KG-SFSMBC-DX to do purification process.

2. Specifications for P-SFSMBC and KG-SFSMBC

	P-SFSMBC-PX	P-SFSMBC/E-PX
Solvent pump	500 mL/min x 4, 100 mL/min x 1 200 bar
Column	SAC column with 30~50 mm in diameter
UV detector	Wavelength Range 190~700nm x2
CO₂ pump	Diaphragm pump with refrigerator 500 g/min, 300 bar	Diaphragm pump with refrigerator 500 g/min, 500 bar
CO₂ recycling	15 L Working tank and demister, 100 bar
CO₂extractor and separator	1L buffer tank, 300 bar 1Gal separators x 3	5L extractor, 500 bar 3L separators x 3
Valves and Fitting	From Swagelok and VICI Valco or equivalents
Instrument and Tubing	Stainless Steel 1/8"~1/4"
Operating System	PLC - Mitsubishi Electric Monitor - Delta Electronics Windows

1) P-SFSMBC

2) KG-SFSMBC

	KG-SFSMBC-DX	Kg-SFSMBC/E-DX
Solvent pump	500 mL/min x 4, 100 mL/min x 1 200 bar
Column	DAC column with 80~120 mm in diameter
UV detector	Wavelength Range 190~700nm x2
CO₂pump	Diaphragm pump with refrigerator 500 g/min, 300 bar	Diaphragm pump with Refrigerator 500 g/min, 500 bar
CO₂ recycling	15 L Working tank and demister, 100 bar
CO₂ extractor and separator	2L buffer tank 300 bar 1Gal separators x 3	5L extractor, 500 bar 3L separator x 3, 100 bar
Valves and Fitting	From Swagelok and VICI Valco or equivalents
Instrument and Tubing	Stainless Steel 1/4"~3/8"
Operating System	PLC - Mitsubishi Electric Monitor - Delta Electronics Windows

3. Industrial size

Columns	200 mm	300 mm	600 mm	1000 mm	12000 mm
Annual Capacity (tons)	15~25	45~65	160~200	480~600	650~750
CO₂ circulation (ton/h)	0.3~0.5	0.65~1.125	2.7~4.5	7.5~12.5	10.8~18
Cosolvent circulation (L/h)	20~100	45~225	180~900	500~2500	720~3600

Application

SF-SMB separation technology device can be used in biomedicine, natural raw materials, and fine chemicals. It is especially suitable for the separation of various lipophilic small molecules. Chromatographic separation of traditional normal phase chromatography and optical alternation, etc.

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Simulated Moving Bed Chromatography